Etobix-T

General Information:

Musculoskeletal pain often involves both inflammation and muscle spasm, causing restricted mobility and discomfort.
Etobix-T provides synergistic action by combining:

• Etoricoxib, which blocks COX-2 enzyme, reducing prostaglandin-mediated inflammation and pain.
• Thiocolchicoside, a semi-synthetic muscle relaxant that acts on GABA-A and glycine receptors, decreasing muscle stiffness and promoting comfort and mobility.

This combination ensures faster recovery, improved flexibility, and better patient compliance with minimal gastric irritation.

Indications and Uses:

Etobix-T is recommended for:

• Acute low back pain and cervical spondylosis
• Muscle spasm associated with sprain or strain
• Painful musculoskeletal disorders
• Osteoarthritis and rheumatoid arthritis
• Post-operative orthopedic pain and stiffness
• Ankylosing spondylitis
• Sports injuries involving muscle contraction

Mechanism of action & benefits:

• Etoricoxib: Selectively inhibits the cyclooxygenase-2 (COX-2) enzyme responsible for pain and inflammation, providing effective analgesia with lower risk of gastric ulcers compared to traditional NSAIDs.
• Thiocolchicoside: Acts as a centrally acting skeletal muscle relaxant by modulating GABA-ergic neurotransmission, reducing involuntary muscle contraction without excessive sedation.

Dosage and Administration:

• Recommended Dose: 1 tablet once or twice daily after meals, as directed by your doctor.
• Route: Oral
• Duration: Short-term use (5–10 days) unless otherwise prescribed. Long-term use should be under medical supervision.

Common Side Effects (Usually Mild & Temporary):

• Gastric discomfort, nausea, or acidity
• Dizziness or mild drowsiness
• Headache or fatigue
• Mild diarrhea or abdominal pain

These symptoms usually resolve with continued use or after meals.

Less Common / Rare Side Effects:

• Elevated blood pressure (rare with prolonged use)
• Fluid retention or swelling of feet
• Skin rash or allergic reaction
• Hepatic enzyme elevation (rare with Etoricoxib)
• Muscle weakness or mild sedation (rare with Thiocolchicoside)

Seek medical advice if any severe or persistent symptom occurs.

Warnings and Precaution:

• Not intended to diagnose, treat, cure, or prevent any disease.
• Avoid prolonged use without medical advice.
• Caution in patients with hypertension, heart disease, liver or kidney impairment, or gastric ulcer history.
• Pregnant and lactating women should consult their physician before use (Thiocolchicoside is not recommended in pregnancy).
• Use with care in elderly patients and those on chronic medications.
• Avoid driving or operating machinery if dizziness occurs.

Drug / Nutrient Interactions:

• Antihypertensives / Diuretics: Etoricoxib may reduce efficacy.
• Anticoagulants (Warfarin, Aspirin): Increased bleeding tendency—monitor INR.
• Corticosteroids / Alcohol: Increase risk of gastric irritation.
• Other NSAIDs: Avoid concurrent use.
• Sedatives or alcohol: May enhance drowsiness due to Thiocolchicoside.

Contraindications:

• Hypersensitivity to Etoricoxib, Thiocolchicoside, or any component of the formulation
• Active peptic ulcer or gastrointestinal bleeding
• Severe hepatic, renal, or cardiac impairment
• Pregnancy and lactation (especially 1st trimester and during breastfeeding)
• Known history of seizures (Thiocolchicoside may lower seizure threshold)

Storage:

Store below 25 °C in a cool, dry place, away from direct sunlight.
Keep out of reach of children.

Do’s and Don’ts:

Disclaimer:

This information is provided for educational purposes only.
Etobix-T Tablets must be consumed strictly under the guidance of your doctor or healthcare professional.
Do not alter or discontinue the prescribed therapy without medical advice.