PEA-Plus

General Information:

Palmitoylethanolamide (PEA) is a naturally occurring lipid molecule produced by the body that helps regulate pain and inflammation. When combined with Alpha Lipoic Acid, Uridine & Cytidine monophosphates, Chromium Polynicotinate, and Curcumin (Mirliq), it offers a comprehensive neuro-restorative approach—addressing the root causes of neuropathic discomfort, nerve degeneration, and mitochondrial dysfunction.

Indications and Uses:

Pea-Plus may be used as adjuvant nutritional support in the management of:

• Peripheral Neuropathy (Diabetic, Chemotherapy-induced, or Idiopathic)
• Lumbar Radiculopathy and Sciatica
• Fibromyalgia and Chronic Pain Syndromes
• Post-Herpetic Neuralgia
• Carpal Tunnel Syndrome
• Neuroinflammation associated with Metabolic Syndrome or Aging
• As a supportive supplement in Neuro-repair and Nerve Regeneration

Mechanism of Action and Benefits:

• PEA (Palmitoylethanolamide): Modulates mast-cell activation and downregulates microglial over-activation, reducing neuropathic pain and neuroinflammation via PPAR-α activation.
• ALA (Alpha Lipoic Acid): Scavenges free radicals, restores nerve conduction velocity, and improves glycemic control.
• Uridine + Cytidine Monophosphate: Provide essential nucleotides for neuronal membrane repair, enhancing axon regeneration and synaptic function.
• Chromium Polynicotinate: Improves insulin sensitivity and reduces metabolic stress that aggravates nerve injury.
• Mirliq® (Curcumin Phytosome): Acts synergistically to inhibit COX-2 and TNF-α pathways, providing neuro-anti-inflammatory protection.

Together, these ingredients enhance nerve repair, restore cellular energy, and reduce chronic neuropathic pain with a natural, non-sedative profile.

Dosage and Administration:

• Recommended Dose: 1 tablet twice daily after meals, or as advised by your healthcare professional.
• Route: Oral

Duration: Typically used for 8–12 weeks or longer based on clinical response.

Common Side Effects (Mild and Self-Limiting):

• Nausea or mild gastric discomfort
• Headache or transient fatigue
• Metallic taste (due to ALA)

These effects usually subside with continued use or when taken after meals.

Less Common / Rare Side Effects:

• Mild skin rash or itching (rare)
• Sleep disturbance in sensitive individuals
• Increased bowel movements or mild laxative effect

Seek medical attention if any allergic reaction or persistent side effect occurs.

Warnings and Precautions:

• Not intended to diagnose, treat, cure, or prevent any disease.
• Avoid self-medication; use only under medical supervision.
• Individuals with hepatic impairment, thyroid disorders, or on hypoglycemic therapy should consult their doctor before use.
• Pregnant or lactating women should take only under medical advice.
• Maintain adequate hydration during therapy.
• Keep away from children.

Drug / Nutrient Interactions:

• Antidiabetic drugs: Monitor blood glucose; ALA and Chromium may enhance hypoglycemic effect.
• Thyroid medications: ALA may influence thyroid hormone uptake; use cautiously.
• Anticoagulants / NSAIDs:Mirliq (Curcumin) may potentiate bleeding tendency.
• Neuropathic drugs: May complement the action of pregabalin, duloxetine, or gabapentin (consult your physician for combined use).

Contraindications:

• Known hypersensitivity to any ingredient in the formulation
• Severe hepatic or renal impairment (use only under supervision)

Active peptic ulcer disease (due to curcumin content)

Storage:

Store below 25°C in a cool, dry place.
Protect from direct sunlight and moisture.
Keep out of reach of children.

Do’s and Don’ts:

Disclaimer:

This information is intended for educational purposes only.
Pea-Plus Tablets must be consumed strictly under the guidance of your doctor or healthcare provider.
Do not change or stop your prescribed dose without consulting your doctor.